[摘要]　目的：研究影响ⅢA期-N2非小细胞肺癌根治术后患者预后的因素。

方法：自1995年3月~1998年2月在上海市胸科医院118例非小细胞肺癌术后病理分期为ⅢA期-N2的患者，对可能影响其生存率的各种临床、病理、治疗方法等因素进行分析，用Kaplan-Meier曲线及Log rank检验生存率差异，Cox单、多因素分析评价各因素对生存率的影响。

结果：118例ⅢA期-N2非小细胞肺癌患者的三年及五年生存率分别为40.5%和18.4%，肿瘤切除情况、N2淋巴结转移的个数和组数及术后化疗周期数均与生存率有关。在多因素分析中，N2淋巴结转移的个数及术后化疗周期数均为影响生存率的重要因素。

结论：N2淋巴结转移的个数及术后化疗周期数是影响ⅢA期-N2非小细胞肺癌预后的重要因素。

[关键词]　非小细胞肺癌；手术治疗；预后

[Abstract]　Purpose：To identify clinical predictors of stage ⅢA-N2 in patients with non-small cell lung cancer.

Methods：From March 1995 to February 1998, 118 patients with pathological stage ⅢA-N2 non-small cell lung cancer who underwent a resection by Shanghai Chest Hospital were analysed. Prognostic factors were estimated from the date of operation using the Kaplan-Meier and log-rank analysis. The Cox regression model evaluated the influence of factors on the survival.

Results：The overall of 3-year and 5-year survivals of the 118 patients were 40.5% and 18.4%. Margin, the number of N2 lymph nodes and stations, the cycles of adjuvant chemotherapy were associated with survival. In a multivariate analysis, the number of N2 lymph nodes and the cycles of adjuvant chemotherapy significantly influenced survival.

Conclusions：The number of N2 lymph nodes and the cycles of adjuvant chemotherapy were important prognostic factors of stage ⅢA-N2 non-small cell lung cancer.

[Key words]　Non-small cell lung cancer；Surgery；Prognosis



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